Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10542
Title: Cytotoxic properties of platinum(IV) and dinuclear platinum(II) complexes and their ligand substitution reactions with guanosine- 50-monophosphate
Authors: Arsenijević, Momir
Milovanovic, Marija
Volarevic, Vladislav
Canovic D.
Arsenijevic, Nebojsa
V. Soldatovic, Tanja
Jovanovic D.
Bugarčić Z.
Journal: Transition Metal Chemistry
Issue Date: 1-Aug-2012
Abstract: The substitution reaction of the Pt(IV) complex [PtCl4(bipy)] with guanosine-50-monophosphate (50-GMP) was studied by UV-Vis spectrophotometry. This reaction was investigated under pseudo-first-order conditions at 37 °C in 25 mMHepes buffer (pH = 7.2) in the presence of 10 mM NaCl to prevent the hydrolysis of the complex. The substitution of chlorides in [{trans-Pt(NH3)2Cl} 2(l-1,2- bis(4-pyridyl)ethane)](ClO4)2 (Pt3) complex by 50-GMP was followed by 1H NMR spectroscopy under second-order conditions. Very similar values for the rate constants of both substitution steps were obtained. The Pt(IV) complexes, [PtCl4(bipy)] and [PtCl4(dach)], as well as dinuclaer Pt(II) [{trans-Pt(NH3)2Cl}2(l-pyrazine)](ClO4)2 (Pt1), [{trans- Pt(NH3)2Cl}2(l-4,40- bipyridyl)](ClO4)2 - DMF (Pt2) and [{trans-Pt(NH3)2Cl}2(l-1,2-bis(4-pyridyl) ethane)](ClO4)2 (Pt3) complexes, displayed potent cytotoxic activity against human ovarium carcinoma cell line TOV21G and lower activity toward human colon carcinoma HCT116 cell line at the same concentrations. Our data indicate that these platinum complexes could be explored further, as potential therapeutic agents for ovarian cancer. © Springer Science+Business Media B.V. 2012.
URI: https://scidar.kg.ac.rs/handle/123456789/10542
Type: article
DOI: 10.1007/s11243-012-9613-4
ISSN: 03404285
SCOPUS: 84865328281
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)

56

Downloads(s)

1

Files in This Item:
File Description SizeFormat 
PaperMissing.pdf
  Restricted Access
29.86 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.