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Title: Low-dimensional compounds containing bioactive ligands. Part XI: Synthesis, structures, spectra, in vitro anti-tumor and antimicrobial activities of 3d metal complexes with 8-hydroxyquinoline-5-sulfonic acid
Authors: Kuchárová, Veronika
Kuchár J.
Zaric, Milan
Canovic P.
Arsenijevic, Nebojsa
Volarevic, Vladislav
Misirkic Marjanovic, Maja
Trajkovic, Vladimir
Radojevic, Ivana
Čomić, Ljiljana
Matik M.
Potočňák I.
Issue Date: 2019
Abstract: © 2019 Five 3d metal [M(H2O)2(SQ)]n complexes, where M is Mn (1), Co (2), Ni (3), Zn (4) and Cu (5), and SQ is the dianion of 8-hydroxyquinoline-5-sulfonic acid have been prepared and characterized by IR spectroscopy and elemental analysis. X-ray structure analysis of 1 and 5 in combination with IR spectroscopy of all five complexes showed that complexes 1–4 are isostructural 2D polymers, while 5 is 1D polymer due to the different bonding character of SQ. Stability of all complexes in DMSO was proved by UV–Vis spectroscopy and for 4 also verified by 1H and 13C NMR spectroscopy. Cytotoxic activity tests against cervical carcinoma HeLa, colon carcinoma HCT116 and normal human fibroblast MRC-5 cell lines showed moderate but selective cytotoxicity of all complexes. Complex 1 exhibited highest activity with IC50 = 39.1 and 33.4 µM, respectively, but is lower than activity of cisplatin (CP) which IC50 = 24.3 and 14.3 µM, respectively. However, their cytotoxic activity against healthy MRC-5 cells (IC50 > 92 µM) is much lower than CP (IC50 = 19.7 µM). Antimicrobial activity of all complexes against 9 strains of pathogenic bacteria, five mould species and two yeast species is negligible.
Type: article
DOI: 10.1016/j.ica.2019.119062
ISSN: 0020-1693
SCOPUS: 2-s2.0-85070928741
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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