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Title: Drug–drug interactions in patients receiving hematopoietic stem cell transplantation
Authors: Pejcic, Ana
Jankovic, Slobodan
Opancina, Valentina
Babic, Goran
Milosavljević, Miloš
Issue Date: 2019
Abstract: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Recipients of hematopoietic stem cell transplantation (HSCT) are exposed to numerous drugs in both pre- and post-transplantation period, which creates an opportunity for drug–drug interactions (DDIs); if clinically relevant DDIs happen, the risk of adverse treatment outcomes is increased. Areas covered: This review is focused on DDIs in recipients of HSCT that were observed and published as clinical trials, case series or case reports. Relevant publications were found by the systematic search of the following online databases: MEDLINE, SCOPUS, EBSCO, and SCINDEX. Expert opinion: The most important DDIs involve cytostatic or immunosuppressant drug on one side, and antimicrobial drugs on the other. The majority of clinically relevant interactions have pharmacokinetic character, involving drug metabolizing enzymes in the liver. Antifungal azoles inhibit metabolism of many cytostatic and immunosuppressant drugs at cytochromes and increase their plasma concentrations. Macrolide antibiotics and fluoroqunolones should be avoided in HSCT recipients, as they have much larger potential for DDIs than other antibiotic groups. HSCT recipients increasingly receive new immunomodulating drugs, and further observational studies are needed to reveal unsuspected DDIs with clinical relevance.
Type: review
DOI: 10.1080/17425255.2019.1552256
ISSN: 1742-5255
SCOPUS: 2-s2.0-85059097076
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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