Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11015
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorDjokovic, Jelena-
dc.contributor.authorTomic Lucic, Aleksandra-
dc.contributor.authorMilovanovic, Olivera-
dc.contributor.authorBazic Sretenovic, Danijela-
dc.contributor.authorVeselinović M.-
dc.contributor.authordjukic, aleksandar-
dc.contributor.authorMatović, Kazimir-
dc.contributor.authorZaric R.-
dc.contributor.authorVeličković-Radovanović R.-
dc.contributor.authorJankovic, Slobodan-
dc.contributor.authorMilovanovic, Jasmina-
dc.date.accessioned2021-04-20T17:16:57Z-
dc.date.available2021-04-20T17:16:57Z-
dc.date.issued2019-
dc.identifier.issn0001-6837-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/11015-
dc.description.abstract© 2019 Polish Pharmaceutical Society. All Rights Reserved. Vitamin D is one of the keys to bone health, and the serum levels of this vitamin are a major concern for postmenopausal women. The aims of this study were to develop a population pharmacokinetic (PPK) model for the clearance of 25-hydroxy vitamin D in non-elderly postmenopausal women and to identify the factors which have a significant influence on its clearance. The study population consisted of postmenopausal women who had been referred for evaluation of bone mineral density (BMD) by DEXA (dual-energy x-ray absorptiometry) scanner. The population pharmacokinetics modeling was conducted using the ADVAN 1 subroutine from a non-linear mixed effects (NONMEM) program, and thirty-two covariates were assessed. A total of 75 serum concentrations were obtained from the same number of postmenopausal women and used for PPK analysis. The mean value of the participantsí age was 57.92 ± 3.93 years and their body weight was 69.76 ± 11.49 kg. A wide range of 25-hydroxy vitamin D concentrations was observed (from 3.41 to 61.92 ng/mL) with a mean value of 26.19 ± 10.95 ng/mL. A total of 32 covariates were examined and preliminary results suggested the influence of six covariates on 25-hydroxy vitamin D clearance. In the final PPK model, however, only one covariate was shown to have a significant impact on the clearance value ñ the mean daily dietary intake dose of vitamin D (DD). These findings offer a preliminary basis on which to determine the level of vitamin D supplementation required by individual postmenopausal women. It could prove particularly important in achieving optimal serum levels of vitamin D in this vulnerable population.-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceActa Poloniae Pharmaceutica - Drug Research-
dc.titlePopulation pharmacokinetics of 25-hydroxy Vitamin D in non-elderly postmenopausal women-
dc.typearticle-
dc.identifier.doi10.32383/appdr/93982-
dc.identifier.scopus2-s2.0-85062507493-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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