Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11341
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dc.contributor.authorStojković, Danijela-
dc.contributor.authorJevtić, Verica-
dc.contributor.authorRadic G.-
dc.contributor.authorDukić M.-
dc.contributor.authorJelic, Ratomir-
dc.contributor.authorZaric, Milan-
dc.contributor.authorAndjelkovic, Marija-
dc.contributor.authorMisic, Milena-
dc.contributor.authorBaskić D.-
dc.contributor.authorTrifunović, Srećko-
dc.date.accessioned2021-04-20T18:06:41Z-
dc.date.available2021-04-20T18:06:41Z-
dc.date.issued2018-
dc.identifier.issn1144-0546-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/11341-
dc.description.abstract© 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. Four new platinum(ii) complexes of general formula [PtCl2(R2-S,S-eddtyr)] (R = ethyl, n-propyl, n-butyl and n-pentyl); S,S-eddtyr = ethylenediamine-N,N′-di-(2,2′-di(4-hydroxy)-benzyl-acetic acid) have been synthesized and characterized by microanalysis, and infrared, 1H NMR and 13C NMR spectroscopy. The in vitro antimicrobial activity of ligands L1-L4 [L = R2-S,S-eddtyr; R = ethyl (L1), n-propyl (L2), n-butyl (L3), n-pentyl (L4)], platinum(ii) complexes C1-C4 [PtCl2(R2-S,S-eddtyr)] [R = ethyl (C1), n-propyl (C2), n-butyl (C3), n-pentyl (C4)] and palladium(ii) complexes C5-C8 [PdCl2(R2-S,S-eddtyr)] [R = ethyl (C5), n-propyl (C6) or n-butyl (C7) or n-pentyl (C8)] was investigated. The cytotoxicity of ligands and platinum(ii) complexes was investigated using MTT assay. The interaction of platinum and palladium complexes [MCl2(R2-S,S-eddtyr)] (M = Pt or Pd) with calf thymus DNA (CT-DNA) was investigated using UV-Vis absorption and fluorescence spectroscopy. The association constant (Kb) estimated from the absorption spectral study and the quenching constant (KSV) calculated from relevant fluorescence quenching data indicate a non-covalent interaction between the metal complex and DNA. Ethidium bromide (EB) competitive studies revealed that complexes C1-C8 could interact with CT-DNA through intercalation. Furthermore, the interactions between human serum albumin (HSA) and the platinum(ii) and palladium(ii) complexes were also investigated by UV-Vis absorption and fluorescence spectroscopy, showing that the new complexes could strongly bind with HSA.-
dc.rightsrestrictedAccess-
dc.sourceNew Journal of Chemistry-
dc.titleStereospecific ligands and their complexes. XXIV. Synthesis, characterization and some biological properties of Pd(II) and Pt(II) complexes with R<inf>2</inf>-: S, S -eddtyr-
dc.typearticle-
dc.identifier.doi10.1039/c7nj04437b-
dc.identifier.scopus2-s2.0-85042683801-
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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