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Назив: The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats
Аутори: Milosevic M.
Paunović, Milica
Matić, Miloš
Ognjanovic, Branka
Saicic Z.
Часопис: Environmental Toxicology and Pharmacology
Датум издавања: 1-дец-2017
Сажетак: © 2017 Elsevier B.V. Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5 mg/kg b.w.) and vitamin C (100 mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20 mg/kg b.w) for 30 days. Fenitrothion caused changes in body weight, food and water intake, and some haematological and biochemical parameters. Fenitrothion altered the glutathione redox status (GSH and GSSG) and decreased activity of antioxidant enzymes (GSH-Px, GST, SOD and CAT), leading to a lipid peroxidation. Selenium and vitamin C, by improving the activity of antioxidants, reduced oxidative stress and a lipid peroxidation, maintaining the values of examined parameters to optimal levels. Therefore, selenium and vitamin C could be useful in providing protection of exposed non-target organisms including people from fenitrothion.
URI: https://scidar.kg.ac.rs/handle/123456789/11376
Тип: journal article
DOI: 10.1016/j.etap.2017.09.016
ISSN: 13826689
SCOPUS: 85029856034
Налази се у колекцијама:Faculty of Science, Kragujevac

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