Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11561
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dc.contributor.authorRistic P.-
dc.contributor.authorSrejovic I.-
dc.contributor.authorNikolic Turnic T.-
dc.contributor.authorStojic, Isidora-
dc.contributor.authorRistic Medic D.-
dc.contributor.authorZivkovic V.-
dc.contributor.authorJakovljevic V.-
dc.date.accessioned2021-04-20T18:39:40Z-
dc.date.available2021-04-20T18:39:40Z-
dc.date.issued2017-
dc.identifier.issn0300-8177-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/11561-
dc.description.abstract© 2016, Springer Science+Business Media New York. Diabetes mellitus is a chronic condition that continues to increase in both incidence and prevalence. Renin–Angiotensin–Aldosterone System is one of the main modulators of chronic hyperglycaemia and, thus, its influence on tissues. Hyperglycaemia-induced oxidative stress is an important factor in diabetic cardiomyopathy. The present study was carried out on 24 adult male Wistar albino rats (8-week-old and with body masses of 190 ± 10 g). We evaluated the influence of acute administration of zofenopril on ex vivo myocardial function from rats with streptozotocin-induced diabetes mellitus, with a special emphasis on cardiodynamic and oxidative stress parameters in diabetic rat hearts. Rats were divided randomly into two groups (12 animals per group): control non-diabetic animals (C) were healthy rats perfused with 1.5 µM of zofenopril, and STZ-treated diabetic animals (DM) were diabetic animals perfused with 1.5 µM of zofenopril 4 weeks after the induction of diabetes. Our results demonstrated that diabetic rats are characterized by a depressed cardiac performance and that oxidative markers are related to alterations in cardiac function in rats with 4 weeks of STZ-induced diabetes. Additionally, the use of zofenopril as a monotherapy slightly diminished cardiac damage induced by chronic hyperglycaemia. However, long-term follow-up intervention trials are necessary to fully demonstrate the benefit of zofenopril in this context. A challenge for future investigations will be to identify the effects of chronic administration or combination therapy with angiotensin-converting enzyme inhibitors in various models of diabetes.-
dc.rightsrestrictedAccess-
dc.sourceMolecular and Cellular Biochemistry-
dc.titleThe effects of zofenopril on cardiac function and pro-oxidative parameters in the streptozotocin-induced diabetic rat heart-
dc.typearticle-
dc.identifier.doi10.1007/s11010-016-2890-z-
dc.identifier.scopus2-s2.0-84996773967-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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