Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11641
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dc.contributor.authorIvković M.-
dc.contributor.authorPantovic Stefanovic M.-
dc.contributor.authorStojadinovic N.-
dc.contributor.authorDunjić-Kostić B.-
dc.contributor.authorVelimirovic M.-
dc.contributor.authorNikolic I.-
dc.contributor.authorJurisic, Vladimir-
dc.contributor.authorLackovic M.-
dc.contributor.authorTotic-Poznanovic S.-
dc.contributor.authorMitrovic-Jovanovic A.-
dc.contributor.authorDamjanovic, Ana-
dc.date.accessioned2021-04-20T18:52:00Z-
dc.date.available2021-04-20T18:52:00Z-
dc.date.issued2017-
dc.identifier.issn0165-0327-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/11641-
dc.description.abstract© 2016 Elsevier B.V. Background Affective temperaments are intermediate phenotypes for major affective disorders and are reported to have a neuroimmune etiopathogenesis. Here we investigated the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in affective temperaments and mood symptoms in healthy adults. Methods Healthy adults (n=94) were screened for psychiatric disorders using the nonpatient version of the Structured Clinical Interview for DSM-IV-I and II. Subjects with medical conditions associated with changes in inflammatory response were excluded, deriving the final sample (n=68). Affective temperaments were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A). State mood symptoms were assessed using the Young Mania Rating Scale and Montgomery–Åsberg Depression Rating Scale. Serum sICAM-1 and sVCAM-1 levels were measured using enzyme-linked immunosorbent assay. Results After adjusting for confounders (age, gender, BMI, and smoking habits), a high negative correlation between depressive and irritable temperament TEMPS-A scores and sVCAM-1 levels was detected. Although we identified no association between sICAM-1 levels and affective temperament scores, sICAM-1 was related to the state severity of manic symptoms. In a multiple linear regression model, sVCAM-1 remained a significant predictor of depressive but not irritable temperament scores. Limitations The temperaments were estimated on the basis of self-report questionnaire. Conclusions Our findings suggest that sVCAM-1 is related to affective temperaments, and it is a trait marker for liability to mood disorders. This relationship between alterations in cellular adhesion and affective temperament may be important for vulnerability to affective disorders.-
dc.rightsrestrictedAccess-
dc.sourceJournal of Affective Disorders-
dc.titlePredictive value of sICAM-1 and sVCAM-1 as biomarkers of affective temperaments in healthy young adults-
dc.typearticle-
dc.identifier.doi10.1016/j.jad.2016.09.017-
dc.identifier.scopus2-s2.0-84989184504-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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