Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12287
Full metadata record
DC FieldValueLanguage
dc.contributor.authorIlić Komatina D.-
dc.contributor.authorJevtić, Verica-
dc.contributor.authorRadic G.-
dc.contributor.authorArsikin K.-
dc.contributor.authorRistic, Biljana-
dc.contributor.authorHarhaji-Trajkovic, Ljubica-
dc.contributor.authorVukovic, Nenad-
dc.contributor.authorSukdolak S.-
dc.contributor.authorKlisuric, Olivera-
dc.contributor.authorTrajkovic, Vladimir-
dc.contributor.authorTrifunović, Srećko-
dc.date.accessioned2021-04-20T20:28:06Z-
dc.date.available2021-04-20T20:28:06Z-
dc.date.issued2014-
dc.identifier.issn0223-5234-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/12287-
dc.description.abstractThe new coumarine derivative, 3-(1-(2-hydroxyethylamino)ethylidene)chroman- 2,4 - dione, and corresponding palladium(II) complex have been synthesized and characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy. The proposed structure of the complex was confirmed on the basis of the X-ray structural study. The palladium(II) complex decreased viability of L929 mouse fibrosarcoma, U251 human glioma and B16 mouse melanoma cell lines in a dose dependent manner, while its ligand exhibited no significant cytotoxicity. The cytotoxic effect of the complex was comparable to that of cisplatin, and mediated by apoptosis associated with oxidative stress, mitochondrial depolarization and caspase activation. Therefore, our results indicate that newly synthesized palladium(II) complex might be a potential candidate for anticancer therapy. © 2014 Elsevier Masson SAS. All rights reserved.-
dc.rightsrestrictedAccess-
dc.sourceEuropean Journal of Medicinal Chemistry-
dc.titleSynthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarine-derived ligand-
dc.typearticle-
dc.identifier.doi10.1016/j.ejmech.2013.12.051-
dc.identifier.scopus2-s2.0-84893217242-
Appears in Collections:Faculty of Science, Kragujevac

Page views(s)

134

Downloads(s)

4

Files in This Item:
File Description SizeFormat 
PaperMissing.pdf
  Restricted Access
29.86 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.