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dc.contributor.authorSimic Vukomanovic, Ivana-
dc.contributor.authorIric Cupic, Violeta-
dc.contributor.authorVucic, Rada-
dc.contributor.authorPetrovic, Marina-
dc.contributor.authorMladenovic, Vladimir-
dc.contributor.authorVeselinović M.-
dc.contributor.authorIgnjatovic, Vladimir-
dc.contributor.authorVučković J.-
dc.description.abstractThe aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250 g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain.-
dc.relation.ispartofArchives of Biological Sciences-
dc.titleThe subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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