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https://scidar.kg.ac.rs/handle/123456789/12430
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DC Field | Value | Language |
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dc.rights.license | restrictedAccess | - |
dc.contributor.author | Pavlovic S. | - |
dc.contributor.author | Zdravkovic, Nemanja | - |
dc.contributor.author | Pejnović, Nada | - |
dc.contributor.author | Djoumerska-Aleksieva I. | - |
dc.contributor.author | Arsenijevic, Nebojsa | - |
dc.contributor.author | Vassilev T. | - |
dc.contributor.author | Lukic, Miodrag | - |
dc.date.accessioned | 2021-04-20T20:48:58Z | - |
dc.date.available | 2021-04-20T20:48:58Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1721-727X | - |
dc.identifier.uri | https://scidar.kg.ac.rs/handle/123456789/12430 | - |
dc.description.abstract | The aim of this study was to investigate the immunomodulatory capacity of native and Fe(II)-exposed intravenous immune globulin (IVIg) in multiple low dose streptozotocin-induced diabetes and to delineate the mechanisms of their influence on immune cell functions. Optimal doses (200-600mg/kg) of IVIg prevented the development of hyperglycemia, glycosuria and attenuated mononuclear cell infiltration in pancreatic islets. Fe(II) exposure of IVIg decreased their optimal therapeutic dose to 100mg/kg which significantly decreased the serum levels of proinflammatory cytokines compared to the same dose of native IVIg. This was accompanied by lower numbers of TNF-α, IFN-γ and IL-17 producing CD4+ T cells and increased frequencies of CD4+IL-10+ and CD4+IL-4 + T cells in the pancreatic lymph nodes and islets on day 16 after diabetes induction. Ferrous ion-exposed IVIg enhanced the bias towards Th2 response while the regulatory Foxp3+ T cells were not affected. Copyright © by BIOLIFE, s.a.s. | - |
dc.rights | info:eu-repo/semantics/restrictedAccess | - |
dc.source | European Journal of Inflammation | - |
dc.title | Enhanced anti-diabetogenic effect of intravenous immune globulin modified by ferrous ion exposure | - |
dc.type | article | - |
dc.identifier.doi | 10.1177/1721727X1401200107 | - |
dc.identifier.scopus | 2-s2.0-84899052009 | - |
Appears in Collections: | Faculty of Medical Sciences, Kragujevac |
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PaperMissing.pdf Restricted Access | 29.86 kB | Adobe PDF | View/Open |
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