Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12430
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dc.rights.licenserestrictedAccess-
dc.contributor.authorPavlovic S.-
dc.contributor.authorZdravkovic, Nemanja-
dc.contributor.authorPejnović, Nada-
dc.contributor.authorDjoumerska-Aleksieva I.-
dc.contributor.authorArsenijevic, Nebojsa-
dc.contributor.authorVassilev T.-
dc.contributor.authorLukic, Miodrag-
dc.date.accessioned2021-04-20T20:48:58Z-
dc.date.available2021-04-20T20:48:58Z-
dc.date.issued2014-
dc.identifier.issn1721-727X-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/12430-
dc.description.abstractThe aim of this study was to investigate the immunomodulatory capacity of native and Fe(II)-exposed intravenous immune globulin (IVIg) in multiple low dose streptozotocin-induced diabetes and to delineate the mechanisms of their influence on immune cell functions. Optimal doses (200-600mg/kg) of IVIg prevented the development of hyperglycemia, glycosuria and attenuated mononuclear cell infiltration in pancreatic islets. Fe(II) exposure of IVIg decreased their optimal therapeutic dose to 100mg/kg which significantly decreased the serum levels of proinflammatory cytokines compared to the same dose of native IVIg. This was accompanied by lower numbers of TNF-α, IFN-γ and IL-17 producing CD4+ T cells and increased frequencies of CD4+IL-10+ and CD4+IL-4 + T cells in the pancreatic lymph nodes and islets on day 16 after diabetes induction. Ferrous ion-exposed IVIg enhanced the bias towards Th2 response while the regulatory Foxp3+ T cells were not affected. Copyright © by BIOLIFE, s.a.s.-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.sourceEuropean Journal of Inflammation-
dc.titleEnhanced anti-diabetogenic effect of intravenous immune globulin modified by ferrous ion exposure-
dc.typearticle-
dc.identifier.doi10.1177/1721727X1401200107-
dc.identifier.scopus2-s2.0-84899052009-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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