Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKolundžija B.-
dc.contributor.authorMarković, Violeta-
dc.contributor.authorStanojkovic, Tatjana-
dc.contributor.authorJoksović, Ljubinka-
dc.contributor.authorMatic, Ivana-
dc.contributor.authorTodorovic N.-
dc.contributor.authorNikolic M.-
dc.contributor.authorJoksović, Milan-
dc.description.abstractA new class of imine derivatives of hybrid chalcone analogues containing anthraquinone scaffold was synthesized and evaluated for their in vitro cytotoxic activity against HeLa, LS174, and A549 cancer cells. The compound 5n with furan ring linked to imino group showed potent activity against all target cells with IC50 values ranging from 1.76 to 6.11 μM. A mode of action study suggested that compounds induced changes typical for apoptosis in HeLa cells. The most active compounds inhibited tubulogenesis and 5h was found to exhibit a strong anti-angiogenic effect. © 2013 Elsevier Ltd. All rights reserved.-
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters-
dc.titleNovel anthraquinone based chalcone analogues containing an imine fragment: Synthesis, cytotoxicity and anti-angiogenic activity-
Appears in Collections:Faculty of Science, Kragujevac

[ Google Scholar ]

Page views(s)


Files in This Item:
File Description SizeFormat 
  Restricted Access
29.86 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.