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Title: Epigenetic memory: gene writer, eraser and homocysteine
Authors: Tyagi S.
Stanisic, Dragana
Singh M.
Issue Date: 2021
Abstract: © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Naturally chromatin remodeling is highly organized, consisting of histone acetylation (opening/relaxation of the compact chromatin structure), DNA methylation (inhibition of the gene expression activity) and sequence rearrangement by shifting. All this is essentially required for proper “in-printing and off-printing” of genes thus ensuring the epigenetic memory process. Any imbalance in ratios of DNA methyltransferase (DNMT, gene writer), fat-mass obesity-associated protein (FTO, gene eraser) and product (function) homocysteine (Hcy) could lead to numerous diseases. Interestingly, a similar process also happens in stem cells during embryogenesis and development. Despite gigantic unsuccessful efforts undertaken thus far toward the conversion of a stem cell into a functional cardiomyocyte, there has been hardly any study that shows successful conversion of a stem cell into a multinucleated cardiomyocyte. We have shown nuclear hypertrophy during heart failure, however; the mechanism(s) of epigenetic memory, regulation of genes during fertilization, embryogenesis, development and during adulthood remain far from understanding. In addition, there may be a connection of aging, loosing of the memory leading to death, and presumably to reincarnation. This review highlights some of these pertinent issues facing the discipline of biology as a whole today.
Type: review
DOI: 10.1007/s11010-020-03895-4
ISSN: 0300-8177
SCOPUS: 2-s2.0-85092191870
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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