Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12579
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorHarrell C.-
dc.contributor.authorVolarevic, Ana-
dc.contributor.authorDjonov, Valentin-
dc.contributor.authorVolarevic, Vladislav-
dc.date.accessioned2021-04-20T21:11:55Z-
dc.date.available2021-04-20T21:11:55Z-
dc.date.issued2021-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/12579-
dc.description.abstract© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceInternational Journal of Molecular Sciences-
dc.titleMesenchymal stem cell-derived exosomes as new remedy for the treatment of neurocognitive disorders-
dc.typereview-
dc.identifier.doi10.3390/ijms22031433-
dc.identifier.scopus2-s2.0-85100109395-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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