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https://scidar.kg.ac.rs/handle/123456789/13571
Full metadata record
DC Field | Value | Language |
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dc.rights.license | restrictedAccess | - |
dc.contributor.author | Dzopalic, Tanja | - |
dc.contributor.author | Kostić, Miloš | - |
dc.contributor.author | Kostic M. | - |
dc.contributor.author | Marjanović, Goran | - |
dc.contributor.author | Guzina J. | - |
dc.contributor.author | Jurisic, Vladimir | - |
dc.contributor.author | Božić Nedeljković B. | - |
dc.date.accessioned | 2021-09-24T22:58:31Z | - |
dc.date.available | 2021-09-24T22:58:31Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0897-7194 | - |
dc.identifier.uri | https://scidar.kg.ac.rs/handle/123456789/13571 | - |
dc.description.abstract | Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs in-vitro. The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the ability to direct the immune response in the co-culture with allogeneic CD4+T cells. Gal-1 reduced the expression of CD80 and CD86 molecules on MoDCs compared to untreated MoDCs. Gal-1 at concentrations of 1 and 6 μg/mL significantly reduced IL-12 production, while the concentration of 3 μg/mL led to its significant increase. Gal-1 in all concentrations induced a significant increase in the production of IL-10. Treatment of MoDCs with 3 and 6 μg/mL of Gal-1 stimulated the production of IL-2 and IFN-γ in the co-culture with CD4+T lymphocytes. This study demonstrated a dual immunomodulatory effect of Gal-1 on MoDCs in terms of immune stimulation and immune suppression, depending on the applied concentration. | - |
dc.rights | info:eu-repo/semantics/restrictedAccess | - |
dc.source | Growth Factors | - |
dc.title | Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells | - |
dc.type | article | - |
dc.identifier.doi | 10.1080/08977194.2021.1947267 | - |
dc.identifier.scopus | 2-s2.0-85109737822 | - |
Appears in Collections: | Faculty of Medical Sciences, Kragujevac |
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File | Description | Size | Format | |
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PaperMissing.pdf Restricted Access | 29.86 kB | Adobe PDF | View/Open |
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