Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13711
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dc.contributor.authorHarrell C.-
dc.contributor.authorPopovska Jovicic, Biljana-
dc.contributor.authorDjonov, Valentin-
dc.contributor.authorVolarevic, Vladislav-
dc.date.accessioned2021-09-24T23:20:40Z-
dc.date.available2021-09-24T23:20:40Z-
dc.date.issued2021-04-01-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/13711-
dc.description.abstractMesenchymal stem cells (MSCs) are adult, immunomodulatory stem cells which reside in almost all postnatal tissues. Viral antigens and damage-associated molecular patterns released from injured and infected cells activate MSCs, which elicit strong antiviral immune response. MSC-sourced interferons and inflammatory cytokines modulate the cytotoxicity of NK cells and CTLs, enhance the antigen-presentation properties of DCs and macrophages, regulate cytokine synthesis in CD4+ T helper cells and promote antibody production in B cells. After the elimination of viral pathogens, MSCs produce immunoregulatory cytokines and trophic factors, prevent the over-activation of immune cells and promote tissue repair and regeneration. In this review article, we summarize the current knowledge on the molecular mechanisms that are responsible for the MSC-dependent elimination of virus-infected cells, and we emphasize the therapeutic potential of MSCs and their secretomes in the treatment of viral diseases.-
dc.relation.ispartofPathogens-
dc.titleMolecular mechanisms responsible for mesenchymal stem cell-based treatment of viral diseases-
dc.typereview-
dc.identifier.doi10.3390/pathogens10040409-
dc.identifier.scopus85104356880-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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