Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVeselinovic, Aleksandar-
dc.contributor.authorPetrović, Snježana-
dc.contributor.authorŽikić V.-
dc.contributor.authorSubotić M.-
dc.contributor.authorJakovljevic, Vladimir-
dc.contributor.authorJeremic, Nevena-
dc.contributor.authorVucic, Vesna-
dc.description.abstractAutism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts and restricted, repetitive patterns of behavior, interests and activities. The maternal status of polyunsaturated fatty acids (PUFA) regulates microglial activity and neuroinflammatory pathways during a child’s brain development. In children with ASD, the metabolism of PUFA is thought to be deficient or abnormal, leading to increased production of proinflammatory cytokines, increased oxidative stress and an imbalance in the formation and action of neurotransmitters. In addition, nutritional deficits in omega-3 PUFA may affect gut microbiota and contribute to ASD by the gut–brain axis. The aim of this study was to review the possible role of neuroinflammation in ASD development and the effect of omega-3 PUFA supplementation in children with ASD. Due to a wide heterogeneity across RCTs, no definitive conclusion about omega-3 PUFA effects in ASD can be drawn. Supplemen-tation with PUFA could be considered as one of the aspects in regulating the biological status of the organism and could provide added value to standard medical and psychological interventions for reducing behavioral deficits.-
dc.sourceMedicina (Lithuania)-
dc.titleNeuroinflammation in autism and supplementation based on omega-3 polyunsaturated fatty acids: A narrative review-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
10.3390-medicina57090893.pdf702.48 kBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons