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Title: In vitro interaction between Agrimonia eupatoria L.: Extracts and antibiotic
Authors: Grujović, Mirjana
Mladenovic, Katarina
Stefanović, Olgica
Zugic Petrovic, Tanja
Čomić, Ljiljana
Issue Date: 2017
Abstract: Synergistic activity between water, acetone, ethanol and diethyl ether extract of Agrimonia eupatoria L. and commonly used antibiotic (ampicillin) were evaluated. Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae and Pseudomonas aeruginosa were used. Interaction between plant extracts and antibiotic were tested by checkerboard method and expressed as fractional inhibitory concentration (FIC) index showed indifferent, additive and synergistic effects. Synergism was observed against E. coli for every combination of agents. FICI values were ranged from 0.03 to 0.29. Inhibitory concentration (IC50) was evaluated for every combination of tested extracts and antibiotic and the best combinations for every tested bacteria were combination of diethyl ether extract + ampicillin and combination of acetone extract + ampicillin.
Type: article
DOI: 10.5937/KgJSci1739157M
ISSN: 1450-9636
Appears in Collections:Faculty of Science, Kragujevac

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