Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке: https://scidar.kg.ac.rs/handle/123456789/13991
Назив: Assessment of chromosomal damage in umbilical blood lymphocytes of newborns from kragujevac in central serbia born 18 years after environmental contamination
Аутори: Milošević-Đorđević, Olivera
Tubić Vukajlović Jovana
Markovic Aleksandra
Grujičić, Darko
Arsenijevic, Petar
Arsenijevic, Slobodan
Датум издавања: 2021
Сажетак: The measurement of micronuclei (MN) in umbilical blood lymphocytes of newborns are increasingly used in cytogenetic epidemiology as one of the preferred methods for assessing chromosomal damage resulted from maternal exposure to mutagen. In the present study, we evaluated the effect of strong environmental contamination (EC) (which occured in the City of Kragujevac, Central Serbia in 1999) on the MN frequency in group of 22 newborns born in Kragujevac 18 years after EC, using cytokinesis-block micronucleus (CBMN) assay. The mean MN frequency in umbilical lymphocytes of these newborns was 5.14 ± 2.17/1,000 binucleated (BN) cells, which is significantly lower than mean MN frequency of newborns born 12 months after contamination (9.36 ± 5.60/1,000 BN cells). Sex of newborns, age of mothers, cigarette smoking, and number of pregnancies did not affect the MN frequency of newborns. Our results showed that in utero exposure to environmental pollution affected genome instability of the fetuses, but that by improving the quality of environmental conditions there was a decrease in mean MN frequency of newborns born 18 years after contamination. In general, genome of umbilical lymphocytes shows a realistic picture of all changes in body and the environment.
URI: https://scidar.kg.ac.rs/handle/123456789/13991
Тип: article
DOI: 10.1620/tjem.255.213
ISSN: 0040-8727
SCOPUS: 2-s2.0-85119151532
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

Број прегледа

839

Број преузимања

14

Датотеке у овој ставци:
Датотека Опис ВеличинаФормат 
10.1620-tjem.255.213.pdf514.36 kBAdobe PDFСличица
Погледајте


Ова ставка је заштићена лиценцом Креативне заједнице Creative Commons