Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMilovanovic, Jasmina-
dc.contributor.authorZaric R.-
dc.contributor.authorRosic N.-
dc.contributor.authorZecevic D.-
dc.contributor.authorMilovanovic, Dragan-
dc.contributor.authorFolic, Marko-
dc.contributor.authorJankovic, Slobodan-
dc.description.abstractVancomycin is a tricyclic glycopeptide antibiotic, mostly used in the treatment of severe staphylococcal and enterococcal infections, especially in orthopedic surgery. The purpose of this analysis was to develop a population pharmacokinetic (PPK) model of vancomycine in hospitalized patients with bone fractures and identify important factors which influence its clearance (CL). A total of ninety-nine measurements of vancomycin serum concentrations were used in our population modeling. A two-compartment model was applied to describe the pharmacokinetics of vancomycin using subroutines ADVAN3 and TRANS4. The study population included patients of both sexes, with the mean age of 62.12±14.69 years and body weight of 80.32±12.44kg. Vancomycin was administered as intravenous infusion with average daily dose of 1772.73±521.34mg. Out of twenty different factors evaluated in the study (including demo-graphic, clinical and laboratory data), only daily dose of vancomycin (DD) and co-medication with piperacillin/tazobactam (PT) showed significant effect on clearance of vancomycin. The final model was described by the following equation: CL (l/h) = 0.03 + 0.000468 x DD + 0.675 x PT. Bootstrapping was used for validation of the final model. In conclusion, the main causes of variability in the clearance of vancomycin among adult patients with bone fractures are daily dose of vancomycin and co-medication with piperacillin/tazobactam.-
dc.sourceSerbian Journal of Experimental and Clinical Research-
dc.titlePopulation pharmacokinetics of vancomycin in adult patients with long bones’ fractures-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
10.2478-sjecr-2019-0025.pdf475.43 kBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons