ANALYSIS OF POTENTIALLY INAPPROPRIATE DRUG PRESCRIBING IN HOSPITALIZED ELDERLY PATIENTS

Abstract

The study was conducted at the Clinical Centre Kragujevac, dur-ing the period March-May 2016. The study population consisted of patients older than 65 that were treated at different departments of the Clinic for Internal Medicine. Data were collected from hospital medical records of patients and anonymous semi-structured questionnaires. STOPP (screening tool of older people's prescrip-tions)/START (screening tool to alert to right treatment) criteria from 2014 were used to monitor the outcome of interest. Based on the outcome PIM (potentially inappropriate drugs)/PPO (poten-tial prescribing omissions), respondents were divided into groups of cases-patients to whom at least one potentially inappropriate drug determined by STOPP criteria was prescribed and those with at least one potential prescribing omission determined by START criteria. Control groups were patients without these out-comes. Most commonly, PIM was detected in the treatment of car-diovascular system diseases (27.12%), followed by the use of drugs that predispose falls in elderly (20.34%). The most im-portant risk factors for the occurrence of PIM were female gender (OR=3.27; 95% CI 1.01-10.64), polypharmacy (5-8 drugs used simultaneously) (OR=3.10; 95% CI 1.11-12.04) and with whom the patient lives (OR=11.26; 95% CI 1.46-86.68). The use of STOPP/START criteria is proved to be efficient in the detection of PIM/PPO at the secondary level of health care. Full attention should always be paid to patients who are at the highest risk for inappropriate drug prescription. Doctors should make their decisions conscientiously and in line with clinical evidence, not blindly believing the pharmaceutical representatives.