THE BENEFITS OF USING NEW TOOLS FOR BEHAVIORAL INVESTIGATIONS IN ANIMAL EXPERIMENTAL MODELS

Abstract

The animal experimental models of emotional disorders attempt to reproduce features of human psychiatric disorders in laboratory animals by correlating the physiological and behavioral changes associated with specific emotional states, the etiology of disorders, and responses on drug treatments. Animal experimental models that accurately recapitulate clinical pathology are indispensable for understanding molecular mechanisms and advancing preclinical studies. Behavioral tests on animal models have been developed over time in two directions: To enable the acquisition of as many valid behavior data as possible, and constructing experimental models and procedures that represent a parallel with certain conditions in humans. In this review we discuss more information for the new tools in behavioral investigations in animal experimental models. Here we described evoked beam-walking (EBW) test as a new test for estimation of anxiety levels. The reliability of that test was confirmed in our studies by using nandrolone decanoate (ND) and testosterone enanthate (TE) in supraphysiological doses. Also, we defined a new approach to estimation of exploratory activity by using these tests and an improvement of detectability in standard evaluation of depressive state levels. Taking into account that behavioral investigation in animal models still has to remain indispensable in conducting of preclinical studies, we assume that new tools that can be applied in this field may improve the quality of research.