Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/18163
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dc.contributor.authorRadojevic, Ivana-
dc.contributor.authorGrujović, Mirjana-
dc.contributor.authorMilošević-Đorđević, Olivera-
dc.contributor.authorTubić Vukajlović, Jovana-
dc.contributor.authorRasic Markovic, Aleksandra-
dc.contributor.authorGrujičić, Darko-
dc.contributor.authorCiric, Andrija-
dc.contributor.authorĐelić, Gorica-
dc.contributor.authorTopuzovic, Marina-
dc.contributor.authorČomić, Ljiljana-
dc.date.accessioned2023-06-07T13:20:55Z-
dc.date.available2023-06-07T13:20:55Z-
dc.date.issued2023-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/18163-
dc.description.abstractIn this research paper, the total phenols (TP), flavonoids (TF), and tannins (TT) content in the acetone and ethyl acetate extracts of Najas marina L. and the identification and quantification of phenolic acids and flavonoids from the ethyl acetate extract were performed. Antioxidant, antimicrobial, and antibiofilm properties of the mentioned extracts were investigated in vitro. The genotoxic potential was analyzed in cultured human peripheral blood lymphocytes (PBL). The TP and TF content was higher in the ethyl acetate extract, dominated by quercetin (172.4 μg mg−1) and ferulic acid (22.74 μg mg−1), while the TT content was slightly higher in the acetone extract. Both extracts tested showed limited antioxidant effects compared to ascorbic acid. The strongest antibacterial activity was observed with Gram-positive bacteria, particularly Staphylococcus aureus (MIC and MMC at 0.31 mg ml−1) and S. aureus ATCC 25923 (MIC at <0.02 mg ml−1), while antifungal activity was limited. Both extracts tested showed better activity on preformed biofilms. Acetone extract had no genotoxic activity but showed significant genoprotective activity against mitomycin C-induced DNA damage in cultured PBLs. Results of our research demonstrate the potential for the development of plant-based antibacterial and biofilm agents.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.sourceLetters in Applied Microbiology-
dc.subjectajas marina l.en_US
dc.subjectphenolic compoundsen_US
dc.subjectantioxidantsen_US
dc.subjectantimicrobial activityen_US
dc.subjectantibiofilm activityen_US
dc.subjectgenotoxic potentialen_US
dc.titlePutative application of Najas marina L. extracts as a source of bioactive compounds and their antioxidant, antimicrobial, antibiofilm, and genotoxic propertiesen_US
dc.typearticleen_US
dc.description.versionPublisheden_US
dc.identifier.doihttps://doi.org/10.1093/lambio/ovad055en_US
dc.type.versionPublishedVersionen_US
Appears in Collections:Faculty of Science, Kragujevac

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