Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке: https://scidar.kg.ac.rs/handle/123456789/21194
Пун извештај метаподатака
Поље DC-а ВредностЈезик
dc.contributor.authorRistić, Marija-
dc.contributor.authorDjukic, Maja-
dc.contributor.authorKosović Perutović, Milica-
dc.contributor.editorZdravkovski, Zoran-
dc.date.accessioned2024-10-11T08:40:17Z-
dc.date.available2024-10-11T08:40:17Z-
dc.date.issued2024-
dc.identifier.isbn978-9989-760-20-4en_US
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/21194-
dc.description.abstractThioamides and their derivatives are an interesting group of compounds because of their structural variations and also because of the combination of hard and soft donor atoms (S and N) that potentially allow coordination – in a variety of binding modes – to a wide range of metal centers, and also because of their biological significance. In our previous studies, we have synthesized a palladium(II) complex with a thioamide-type ligand of the formula [PdL2Cl2] (L= ethyl 4-[1-amino-2-cyano- 3-(methylamino)-3-thioxo-1-propen-1-yl]-1-piperazine-1-carboxylate), whose ability to interact with HSA was investigated fluorometrically.1 In this work, research was continued toward the study of interactions with calf thymus DNA in the presence of EB (ethidium bromide) or HOE (Hoescht 33258), with the aim of determining the binding affinity, binding strength and the binding mode. The results obtained showed that this complex binds moderately to the DNA via the minor groove, and that the quenching mechanism is static (Table 1). Table 1. The Stern–Volmer constants (Ksv) and binding constants (Kb) for Pd(II) complex from CT DNA-EB and CT DNA-HOE fluorescence. Complex KSV(EB) [M-1] Kb(EB) [M-1] KSV(HOE) [M-1] Kb(HOE) [M-1] [PdL2Cl2] 2.58 × 104 6.59 × 103 3.77 × 104 2.76 × 105en_US
dc.language.isoenen_US
dc.publisherSociety of Chemists and Technologists of Macedoniaen_US
dc.subjectPalladium(II) complexen_US
dc.subjectthioamidesen_US
dc.subjectDNA interactionen_US
dc.subjectminor grooveen_US
dc.titleDNA Interactions of Palladium (II) Complex Containing a Thioamide-Type Liganden_US
dc.typeconferenceObjecten_US
dc.description.versionPublisheden_US
dc.type.versionPublishedVersionen_US
Налази се у колекцијама:Faculty of Science, Kragujevac

Број прегледа

423

Број преузимања

13

Датотеке у овој ставци:
Датотека Опис ВеличинаФормат 
DNA Interactions of Palladium (II) Complex Containing a thioamide type ligand_2024-27th-Congress-Book-of-SCTM.pdf766.21 kBAdobe PDFСличица
Погледајте


Ставке на SCIDAR-у су заштићене ауторским правима, са свим правима задржаним, осим ако није другачије назначено.