SYNTHESIS, CHARACTERIZATION AND HSA INTERACTIONS OF NEW [PDL2CL2] COMPLEX

Abstract

In this report, we have synthesized a new palladium(II) complex, [PdL2Cl2], where L = 5- (methylamino)-3-morpholine-4-ylisothiazole-4-carbonitrile. To an aqueous solution (15 mL) of K2[PdCl4] (0.1632 g, 0.50 mmol) was added 15 mL of a methanolic ligand solution (0.2243 g, 1 mmol). The resulting mixture was stirred for 1 hour at room temperature until the reagents had completely dissolved. The solution was then filtered off under vacuum and washed with diethyl ether, yielding an orange powdery residue. The characterization of the synthesized complex [PdL2Cl2] was carried out by elemental microanalysis, IR spectroscopy and determination of the melting point. The interaction of the new complex with human serum albumin (HSA) was investigated by fluorescence spectroscopy. The high value of the binding constant, Kb, and the Stern-Volmer quenching constant, KSV, are the result of good binding of the complex to HSA.