Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8402
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorGojak R.-
dc.contributor.authorHadžiosmanović V.-
dc.contributor.authorBaljic R.-
dc.contributor.authorZecevic L.-
dc.contributor.authorĆoric J.-
dc.contributor.authorMijailovic, Zeljko-
dc.date.accessioned2020-09-19T15:39:04Z-
dc.date.available2020-09-19T15:39:04Z-
dc.date.issued2019-
dc.identifier.issn1452-8258-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/8402-
dc.description.abstract© 2019 Refet Gojak, Vesna Hadžiosmanović, Rusmir Baljić, Lamija Zečević, Jozo Ćorić, Željko Mijailović published by Sciendo. HIV infection is characterized by progressive depletion of CD4+ T cells due to their reduced synthesis and increased destruction followed by marked activation and expansion of CD8+ T lymphocytes. CD4/CD8 ratio was traditionally described as a marker of immune system ageing in the general population, but it increasingly appears as a marker of different outcomes in the HIV-infected population. The main objective of this study is to examine the power of CD4/CD8 ratio in predicting the occurrence of metabolic syndrome (MetS) in HIV-positive patients receiving cART therapy. 80 HIV/AIDS subjects were included in a retrospective case-control study. Flow cytometry was used to determine the percentage of CD4+ and CD8+ cells in peripheral blood of these patients. The values of biochemical parameters (triglycerides, HDL, blood sugar, blood counts), immunological parameters (CD4/CD8, PCR), anthropometric measurements and type of cART therapy were evaluated in this study. After six months of cART therapy 19 (23.8%) subjects had all the elements necessary for making the diagnosis of MetS. Using multivariate analysis CD4/CD8 ratio was statistically significant (p < 0.05) and had the largest effect on development of MetS (Wald = 9.01; OR = 0.45), followed by cART (Wald = 7.87; OR = 0.10) and triglycerides (Wald = 5.27; OR = 1.7). On the other hand, body weight and waist circumference showed no statistically significant effect on the development of MetS after six months of cART, p > 0.05. CD4/CD8 ratio proved to be a significant marker for prediction of metabolic syndrome in HIV/AIDS patients.-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceJournal of Medical Biochemistry-
dc.titleCD4/CD8 ratio as a predictor for the occurrence of metabolic syndrome in HIV / AIDS patients during 6 months of cART therapy-
dc.typearticle-
dc.identifier.doi10.2478/jomb-2018-0049-
dc.identifier.scopus2-s2.0-85070692260-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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