Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8461
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorNikolic I.-
dc.contributor.authorSrejovic I.-
dc.contributor.authorStojic, Isidora-
dc.contributor.authorJeremic, Jovana-
dc.contributor.authorFolic, Marko-
dc.contributor.authorMatic, Aleksandar-
dc.contributor.authorRakocevic M.-
dc.contributor.authorJancic S.-
dc.contributor.authorJakovljevic B.-
dc.contributor.authorObrenović R.-
dc.contributor.authorDjuric D.-
dc.contributor.authorZivkovic V.-
dc.date.accessioned2020-09-19T15:49:26Z-
dc.date.available2020-09-19T15:49:26Z-
dc.date.issued2019-
dc.identifier.issn1820-8665-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/8461-
dc.description.abstract© 2019, University of Kragujevac, Faculty of Science. All rights reserved. The strong association among the risk of coronary artery diseases (CAD), high levels of LDL-C and low levels of HDL-C is well established. Hyperhomocysteinaemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) and causes endothelial dysfunction, a hallmark of atherosclerosis. In this study, we ascertained the influence of statins on the atherogenic index, as an indicator and a significant adjunct for predicting atherosclerosis in hyperhomocysteinaemic male Wistar albino rats. For 4 weeks, the animals were fed with one of the following diets (Mucedola SRL., Milan, Italy): standard rodent chow; a diet enriched in methionine with no deficiency in B vitamins or a diet enriched in methionine and deficient in B vitamins. The animals were simultaneously exposed to a pharmacology treatment with atorvastatin at dose of 3 mg/kg/day i.p. or simvastatin, at dose of 5 mg/kg/day i.p. We measured weight gain, food intake, and FER and determined the concentrations of biochemical parameters of dyslipidaemia (TC, TGs, LDL-C, VLDL-C, and HDL-C), AI, and CRR. A histopathological examination was conducted on portions of the right and left liver lobes from each animal. A connection between Hhcy and dyslipidaemia was indicated by the findings of biochemical and histological analyses, suggesting that Hhcy was a pro-atherogenic state. An improvement in the lipid profile along with a decrease in the atherogenic index by statins suggests that atorvastatin and simvastatin could be useful antiatherogenic agents, with protective activities during hyperhomocysteinaemia.-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceSerbian Journal of Experimental and Clinical Research-
dc.titleAtherogenic impact of homocysteine: Can hmg-coa reductase inhibitors additionally influence hyperhomocysteinaemia?-
dc.typearticle-
dc.identifier.doi10.1515/SJECR-2017-0055-
dc.identifier.scopus2-s2.0-85054776069-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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