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Title: Effects of ischemic and proton pump inhibitors preconditioning on oxidative stress of isolated rat heart
Authors: Jeremić N.
Zivkovic V.
Srejovic I.
Jeremic, Jovana
Petkovic, Anica
Bradic, Jovana
Jakovljevic V.
Issue Date: 2018
Abstract: © 2018, University of Kragujevac, Faculty of Science. All rights reserved. Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2 -), superoxide anion radicals (O2 -), index of lipid peroxidation (TBARS) and hydrogen peroxide (H2O2) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors. Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism. Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia.
Type: article
DOI: 10.1515/SJECR-2016-0008
ISSN: 1820-8665
SCOPUS: 2-s2.0-85052292046
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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