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Назив: Comparison of training and detraining on redox state of rats: Gender specific differences
Аутори: Bradic, Jovana
Ruzicic R.
Jeremic, Jovana
Petkovic, Anica
Stojic, Isidora
Nikolic I.
Zivkovic V.
Srejovic I.
Radovanovic, Dragan
Jakovljevic V.
Часопис: General Physiology and Biophysics
Датум издавања: 1-јан-2018
Сажетак: © 2018 Slovak Academy of Sciences. All rights reserved. Given the fact that oxidative stress response induced by training/detraining has still not been clarified and may be influenced by gender, the aim of our investigation was to compare the effects of swimming training and detraining on oxidative and antioxidative parameters in rats, with a special focus on sex differences. Wistar albino rats (n = 64) were divided into 4 groups: control, trained group, groups exposed to 2 and 4 weeks of detraining. Each group included two subgroups: males and females. After sacrificing, hearts were isolated and retrogradely perfused according to Langendorff technique. Levels of superoxide anion radical, hydrogen peroxide, nitrites and thiobarbituric acid reactive substances were measured in plasma and coronary venous effluent, while reduced glutathione, activities of superoxide dismutase and catalase were measured in erythrocytes. Our results indicate that swimming training doesn't promote oxidative damage, nor act protectively within the heart. However, 2 and 4 weeks of detraining led to a partial lost in exercise-induced adaptation. It seems that moderate-intensity physical exercise of sufficient duration leads to beneficial adaptations, which may be partially lost during detraining period. Positive antioxidative effects of training remained longer in males. Findings of present study may help in elucidation of training and detraining effects on modulation of redox homeostasis, especially from aspect of gender differences.
URI: https://scidar.kg.ac.rs/handle/123456789/8684
Тип: journal article
DOI: 10.4149/gpb_2017053
ISSN: 02315882
SCOPUS: 85048490089
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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