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Title: Naloxone Antagonizes Soman-induced Central Respiratory Depression in Rats
Authors: Škrbić R.
Stojiljković M.
Cetkovic S.
Dobric M.
Jeremic, Dejan
Vulovič M.
Issue Date: 2017
Abstract: © 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society) The influence of naloxone on respiration impaired by the highly toxic organophosphate nerve agent soman in anaesthetized rats was investigated. Soman, administered in a dose that was ineffective in blocking the electrically induced contractions of the phrenic nerve-diaphragm preparation in situ, induced a complete block of the spontaneous respiratory movements of the diaphragm, indicating the domination of central over the peripheral effects. Naloxone dose-dependently antagonized the soman-induced respiratory blockade. Atropine, at a dose that was per se ineffective in counteracting soman-induced respiratory depression, potentiated the protective effects of naloxone and completely restored respiration. Naloxone remained completely ineffective in antagonizing respiratory depression induced by the muscarinic receptor agonist the oxotremorine. It is assumed that naloxone antagonizes soman-induced respiratory inhibition by blocking endogenous opioidergic respiratory control pathways that are independent of the stimulation of muscarinic receptors.
Type: article
DOI: 10.1111/bcpt.12745
ISSN: 1742-7835
SCOPUS: 2-s2.0-85015347069
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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