Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/8846
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorMilovanovic, Jelena-
dc.contributor.authorPopović B.-
dc.contributor.authorMilovanovic, Marija-
dc.contributor.authorKvestak D.-
dc.contributor.authorArsenijevic A.-
dc.contributor.authorStojanovic B.-
dc.contributor.authorTanaskovic, Irena-
dc.contributor.authorKrmpotic A.-
dc.contributor.authorArsenijevic, Nebojsa-
dc.contributor.authorJonjic S.-
dc.contributor.authorLukic, Miodrag-
dc.date.accessioned2020-09-19T16:50:03Z-
dc.date.available2020-09-19T16:50:03Z-
dc.date.issued2017-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/8846-
dc.description.abstract© 2017 Milovanovic, Popovic, Milovanovic, Kvestak, Arsenijevic, Stojanovic, Tanaskovic, Krmpotic, Arsenijevic, Jonjic and Lukic. In contrast to C57BL/6 mice, BALB/c mice are relatively resistant to the induction of experimental autoimmune encephalomyelitis (EAE) after challenge with MOG35-55 peptide. Here, we provide the first evidence that infection with murine cytomegalovirus (MCMV) in adulthood abrogates this resistance. Infected BALB/c mice developed clinical and histological signs similar to those seen in susceptible C57BL/6 mice. In addition to CD4+ cells, large proportion of cells in the infiltrate of diseased BALB/c mice was CD8+, similar with findings in multiple sclerosis. CD8+ cells that responded to ex vivo restimulation with MOG35-55 were not specific for viral epitopes pp89 and m164. MCMV infection favors proinflammatory type of dendritic cells (CD86+CD40+CD11c+) in the peripheral lymph organs, M1 type of microglia in central nervous system, and increases development of Th1/Th17 encephalitogenic cells. This study indicates that MCMV may enhance autoimmune neuropathology and abrogate inherent resistance to EAE in mouse strain by enhancing proinflammatory phenotype of antigen-presenting cells, Th1/Th17, and CD8 response to MOG35-55.-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceFrontiers in Immunology-
dc.titleMurine cytomegalovirus infection induces susceptibility to EAE in resistant BALB/c mice-
dc.typearticle-
dc.identifier.doi10.3389/fimmu.2017.00192-
dc.identifier.scopus2-s2.0-85014309070-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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