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https://scidar.kg.ac.rs/handle/123456789/8981
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DC Field | Value | Language |
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dc.rights.license | openAccess | - |
dc.contributor.author | Stojanovic, M | - |
dc.contributor.author | Zivkovic, Vladimir | - |
dc.contributor.author | Srejovic, Ivan | - |
dc.contributor.author | Jakovljevic, Vladimir | - |
dc.contributor.author | Jeremic, Nevena | - |
dc.contributor.author | Djuric D. | - |
dc.date.accessioned | 2020-09-19T17:10:22Z | - |
dc.date.available | 2020-09-19T17:10:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0231-424X | - |
dc.identifier.uri | https://scidar.kg.ac.rs/handle/123456789/8981 | - |
dc.description.abstract | © 2016 Akadémiai Kiadó, Budapest. This study aimed to assess the role of H2S in homocysteine-induced cardiodynamic effects in the isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique. The maximum and minimum rates of pressure in the left ventricle (dp/dt max, dp/dt min), systolic and diastolic left ventricular pressures (SLVP, DLVP), heart rate (HR), and coronary flow (CF) were measured. A spectrophotometrical method was used to measure the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid reactive substances, TBARS), nitrite level (NO2-), superoxide anion radicals (O2•-), and hydrogen peroxide (H2O2) concentrations. The administration of 10 μmol/l DL-homocysteine (DL-Hcy) alone decreased dp/dt max, SLVP, and CF but did not change any oxidative stress parameters. The administration of 10 μmol/l DL-propargylglycine (DL-PAG) decreased all cardiodynamic parameters and increased the concentration of O2•-. The co-administration of DL-Hcy and DL-PAG induced a significant decrease in all estimated cardiodynamic parameters and decreased the concentration of NO2- and O2 •- but increased the levels of TBARS and H2O2. Homocysteine shows a lower pro-oxidative effect in the presence of hydrogen sulfide (H2S), which indicates a potential anti-oxidative capacity of H2S. | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Acta Physiologica Hungarica | - |
dc.title | The role of hydrogen sulfide in homocysteine-induced cardiodynamic effects and oxidative stress markers in the isolated rat heart | - |
dc.type | article | - |
dc.identifier.doi | 10.1556/2060.103.2016.4.3 | - |
dc.identifier.scopus | 2-s2.0-85015824779 | - |
Appears in Collections: | Faculty of Medical Sciences, Kragujevac |
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10.1556-2060.103.2016.4.3.pdf | 101.81 kB | Adobe PDF | View/Open |
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