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Назив: Cannabis as a possible treatment for spasticity in multiple sclerosis
Аутори: Vesić, Katarina
Dejanovic S.
Borovcanin, Milica
Samardzic J.
Toncev, Gordana
Часопис: Serbian Journal of Experimental and Clinical Research
Датум издавања: 1-мар-2016
Сажетак: © 2016, University of Kragujevac, Faculty of Science. All Rights Reserved. The therapeutic potential of cannabis has been known for centuries. Cannabinoids express their effects throughtwotypes of receptors, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). Present studies indicate that cannabis-based drugs can make a positive impact in the treatment of different diseases. For many years, multiple sclerosis patients have self-medicated with illegal street cannabis to alleviate spasticity, a common and debilitating symptom that impairs quality of life. Nabiximols is the cannabis-based medicine approved in many countries as an add-on therapy for symptom improvement in patients with spasticity who have not responded adequately to other medications. Adverse events such as dizziness, diarrhoea, fatigue, nausea, headache and somnolence occur quite frequently with nabiximols, but they are generally of mild-to-moderate intensity and their incidence can be markedly reduced by gradual uptitration. The prerequisite for the therapeutic use of cannabis in Serbia arerequires legal clarifi cation for the use of the drug in a clinical environment.
URI: https://scidar.kg.ac.rs/handle/123456789/9077
Тип: review
DOI: 10.1515/SJECR-2015-0047
ISSN: 18208665
SCOPUS: 84961574721
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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