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DC Field | Value | Language |
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dc.rights.license | BY-NC-ND | - |
dc.contributor.author | Mijuskovic M. | - |
dc.contributor.author | Stanojevic, Ivan | - |
dc.contributor.author | Milovic N. | - |
dc.contributor.author | Cerović S. | - |
dc.contributor.author | Petrovic, Dejan | - |
dc.contributor.author | Jovanovic D. | - |
dc.contributor.author | Aleksić P. | - |
dc.contributor.author | Kovacevic B. | - |
dc.contributor.author | Andjelic T. | - |
dc.contributor.author | Terzic B. | - |
dc.contributor.author | Djukic, Mirjana | - |
dc.contributor.author | Vojvodic, Danilo | - |
dc.date.accessioned | 2020-09-19T17:25:29Z | - |
dc.date.available | 2020-09-19T17:25:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0042-8450 | - |
dc.identifier.uri | https://scidar.kg.ac.rs/handle/123456789/9083 | - |
dc.description.abstract | © 2016, Institut za Vojnomedicinske Naucne Informacije/Documentaciju. All rights reserved. Background/Aim. Kidney injury molecule-1 (KIM-1) and aquaporin-1 (AQP-1) are potential early urinary biomarkers of clear renal cell carcinoma (cRCC). The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of operation (radical or partial nephrectomy) in patients with cRCC. Methods. Urinary concentrations of urinary KIM-1 (uKIM-1) and urinary AQP-1 (uAQP-1) were determined by commercially available ELISA kits. The analysis included 40 patients undergoing partial or radical nephrectomy for cRCC and 40 age-and sex-matched healthy adult volunteers. Results. The median preoperative concentrations of KIM-1 in the cRCC group [0.724 ± 1.120 ng/mg urinary creatinine (Ucr)] were significantly greater compared with controls (healthy volunteers) (0.210 ± 0.082 ng/mgUcr) (p = 0.0227). Postoperatively, uKIM-1 concentration decreased significantly to control values (0.177 ± 0.099 ng/mgUcr vs 0.210 ± 0.082 ng/mgUcr, respectively). The size, grade and stage of tumor were correlated positively with preoperative uKIM-1 concentrations. Contrary to these results, concentrations of uAQP-1 in the cRCC group were significantly lower (0.111 ± 0.092 ng/mgUcr) compared with the control group (0.202 ± 0.078 ng/mgUcr) (p = 0.0014). Postoperatively, the concentrations of uAQP-1 increased progressively up to control values, approximately. We find no significant correlation between preoperative uAQP-1 concentrations and tumor size, grade and stage. Conclusion. uKIM-1 was found to be a reliable diagnostic marker of cRCC, based on its significantly increased values before and decreased values after the nephrectomy. | - |
dc.rights | openAccess | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Vojnosanitetski Pregled | - |
dc.title | Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers | - |
dc.type | article | - |
dc.identifier.doi | 10.2298/VSP150124006M | - |
dc.identifier.scopus | 2-s2.0-84959339272 | - |
Appears in Collections: | Faculty of Medical Sciences, Kragujevac |
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File | Description | Size | Format | |
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10.2298-VSP150124006M.pdf | 414.64 kB | Adobe PDF | View/Open |
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