Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9294
Full metadata record
DC FieldValueLanguage
dc.rights.licenseBY-NC-ND-
dc.contributor.authorVucicevic, Ksenija-
dc.contributor.authorJakovljevic V.-
dc.contributor.authorSretenovic J.-
dc.contributor.authorTosić N.-
dc.contributor.authorKostić Z.-
dc.contributor.authorGlumac I.-
dc.contributor.authorColovic, Mirjana-
dc.contributor.authorČolović N.-
dc.contributor.authorPavlović N.-
dc.contributor.authorKaran-Djurasevic T.-
dc.date.accessioned2020-09-19T17:56:59Z-
dc.date.available2020-09-19T17:56:59Z-
dc.date.issued2015-01-01-
dc.identifier.issn18208665-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/9294-
dc.description.abstract© 2015 University of Kragujevac, Faculty of Science. All rights reserved. Chronic lymphocytic leukaemia (CLL) manifests as clonal expansion of mature B lymphocytes, whose accumulation is primarily attributed to the dysregulation of apoptosis. Aberrant expression, as well as genetic alterations within various Bcl2 family members and central regulators of the intrinsic, mitochondriamediated apoptotic pathway all hasve been observed in CLL. Here, we report the expression analysis of the anti-apoptotic Bcl2 gene in a cohort of 58 CLL patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) analysis revealed a significant overexpression of Bcl2 mRNA in CLL samples compared to control samples (p=<0.001). Receiver operating characteristic (ROC) analysis showed that the level of Bcl2 expression exerts a high discriminatory power between patients and healthy subjects (A=0.98, 95% CI=0.95-1.009, p<0.0001).-
dc.relation.ispartofSerbian Journal of Experimental and Clinical Research-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleExpression of the BCL2 gene in chronic lymphocytic leukaemia patients-
dc.typearticle-
dc.identifier.doi10.1515/SJECR-2015-0024-
dc.identifier.scopus84943382626-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)

70

Downloads(s)

5

Files in This Item:
File Description SizeFormat 
10.1515-SJECR-2015-0024.pdf685.96 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons