Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке: https://scidar.kg.ac.rs/handle/123456789/9415
Назив: Protective effects of oestradiol against cadmium-induced changes in blood parameters and oxidative damage in rats
Аутори: Mladenovic J.
Ognjanovic, Branka
Đorđević, Nevena
Matić, Miloš
Knežević V.
Štajn A.
Saicic Z.
Часопис: Arhiv za Higijenu Rada i Toksikologiju
Датум издавања: 1-јан-2014
Сажетак: The aim of this study was to investigate the protective effects of oestradiol (E2, 4 mg kg-1 b.w. i.p.) against cadmium-induced (Cd, 2 mg kg-1 b.w. i.p.) blood changes in rats. Cadmium induced a significant decline in haemoglobin, haematocrit, and total erythrocyte, lymphocyte, and thrombocyte count, whereas total leukocytes and granulocytes increased. A significant increase was also observed in serum cholesterol, triglycerides, glucose, AST, and ALT activities, whereas total protein and albumin levels dropped significantly. Administration of E2 in combination with Cd alleviated most of these adverse effects. In terms of oxidative stress, Cd significantly increased oxygen-free radicals (O2•- and H2O2) in neutrophils and lipid peroxidation in erythrocytes, whereas E2 treatment reversed these changes to control values. Acute Cd poisoning significantly lowered antioxidant enzyme (SOD and CAT) activity and the level of non-enzymatic antioxidants (GSH and vitamin E), while increasing in GSSG. Treatments with E2 reversed Cd-induced effects on the antioxidant defences and significantly lowered Cd-induced oxidative damage in erythrocytes. This study suggests that exogenous E2 effectively restores redox balance in rat erythrocytes and counters adverse haematological and biochemical effects of Cd poisoning. It also improves the antioxidant capacity of erythrocytes, acting in synergy with endogenous antioxidants.
URI: https://scidar.kg.ac.rs/handle/123456789/9415
Тип: article
DOI: 10.2478/10004-1254-65-2014-2405
ISSN: 00041254
SCOPUS: 84899826119
Налази се у колекцијама:Faculty of Science, Kragujevac

Број прегледа

79

Број преузимања

15

Датотеке у овој ставци:
Датотека Опис ВеличинаФормат 
10.2478-10004-1254-65-2014-2405.pdf593.75 kBAdobe PDFСличица
Погледајте


Ставке на SCIDAR-у су заштићене ауторским правима, са свим правима задржаним, осим ако није другачије назначено.