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dc.contributor.authorZivkovic V.-
dc.contributor.authorJakovljevic V.-
dc.contributor.authorPechanova O.-
dc.contributor.authorSrejovic I.-
dc.contributor.authorJoksimovic, Jovana-
dc.contributor.authorSelakovic, Dragica-
dc.contributor.authorBarudzic N.-
dc.contributor.authorDjuric D.-
dc.description.abstractConsidering the adverse effects of DL-homocysteine thiolactone hydrochloride (DL-Hcy TLHC) on vascular function and the possible role of oxidative stress in these mechanisms, the aim of this study was to assess the influence of DL-Hcy TLHC alone and in combination with specific inhibitors of important gasotransmitters, such as L-NAME, DL-PAG, and PPR IX, on cardiac contractility, coronary flow, and oxidative stress markers in an isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique at a 70 cm H and administered 10 M DL-Hcy TLHC alone or in combination with 30 M L-NAME, 10 M DL-PAG, or 10 M PPR IX. The following parameters were measured: dp/dt max, dp/dt min, SLVP, DLVP, MBP, HR, and CF. Oxidative stress markers were measured spectrophotometrically in coronary effluent through TBARS, NO O 2 -, and Hconcentrations. The administration of DL-Hcy TLHC alone decreased dp/dt max, SLVP, and CF but did not change any oxidative stress parameters. DL-Hcy TLHC with L-NAME decreased CF, O 2 -, H and TBARS. The administration of DL-Hcy TLHC with DL-PAG significantly increased dp/dt max but decreased DLVP, CF, and TBARS. Administration of DL-Hcy TLHC with PPR IX caused a decrease in dp/dt max, SLVP, HR, CF, and TBARS. © 2013 Vladimir Zivkovic et al.-
dc.sourceBioMed Research International-
dc.titleEffects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: The role of different gasotransmitters-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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