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Назив: Stem cell-based therapy for spinal cord injury
Аутори: Volarevic, Vladislav
Erceg S.
Bhattacharya S.
Stojkovic P.
Horner P.
Stojkovíc M.
Часопис: Cell Transplantation
Датум издавања: 7-авг-2013
Сажетак: Stem cells (SCs) represent a new therapeutic approach for spinal cord injury (SCI) by enabling improved sensory and motor functions in animal models. The main goal of SC-based therapy for SCI is the replacement of neurons and glial cells that undergo cell death soon after injury. Stem cells are able to promote remyelination via oligodendroglia cell replacement to produce trophic factors enhancing neurite outgrowth, axonal elongation, and fiber density and to activate resident or transplanted progenitor cells across the lesion cavity. While several SC transplantation strategies have shown promising yet partial efficacy, mechanistic proof is generally lacking and is arguably the largest impediment toward faster progress and clinical application. The main challenge ahead is to spur on cooperation between clinicians, researchers, and patients in order to define and optimize the mechanisms of SC function and to establish the ideal source/s of SCs that produce efficient and also safe therapeutic approaches. © 2013 Cognizant Comm. Corp.
URI: https://scidar.kg.ac.rs/handle/123456789/9472
Тип: review
DOI: 10.3727/096368912X657260
ISSN: 09636897
SCOPUS: 84881004447
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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