Effects of aurothiomalate and gold(III) complexes on spontaneous motility of isolated human oviduct

Abstract

Organic gold complexes have different biological activity, depending on their potential for interactions with key functional molecules.The aim of this study was to investigate potential of several newly synthesized organic gold complexes to influence spontaneous motility of the Fallopian tubes.The effects of [Au(bipy)Cl 2 ] + (dichloride(2,20-bipyridyl) aurate(III)-ion), aurothiomalate, [Au(DMSO) 2 Cl 2 ]Cl and DMSO on spontaneous motility of Fallopian tubes were tested on the isolated tube segments in vitro. Aurothiomalate (from 2.9 × 10 -9 to 4.9 × 10 -4 M/l), [Au(bipy)Cl 2 ]Cl (from 3.3 × 10 -9 to 4.2 9 10 -5 M/l) and DMSO (from 1.9 × 10 -8 to 1.0 × 10 -5 M/l) did not affect spontaneous contractions of the isolated Fallopian tube ampulla, while [Au(DMSO) 2 Cl 2 ]Cl (from 2.9 × 10 -9 to 4.2 × 10 -5 M/l) showed concentration- dependent increase (stimulation) of spontaneous contractions of the isolated Fallopian tube isthmus, and remained without effect on the isolated ampulla.The drugs designed as organic gold complexes with weaker bonds between the gold itself and organic part of a molecule could adversely affect motility of the Fallopian tubes, and theoretically fertility of women taking such drugs in their reproductive age. © Springer Science+Business Media, LLC. 2012.