Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9835
Full metadata record
DC FieldValueLanguage
dc.contributor.authorArsenijević, Momir-
dc.contributor.authorMilovanovic, Marija-
dc.contributor.authorVolarevic, Vladislav-
dc.contributor.authorKesić, Ana-
dc.contributor.authorKanjevac, Tatjana-
dc.contributor.authorArsenijevic, Nebojsa-
dc.contributor.authordjukic, aleksandar-
dc.contributor.authorBugarčić Z.-
dc.date.accessioned2021-04-20T14:10:43Z-
dc.date.available2021-04-20T14:10:43Z-
dc.date.issued2012-01-01-
dc.identifier.issn15734064-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/9835-
dc.description.abstractWe have studied the kinetics of the complex formation of gold(III) complexes, [Au(en)Cl 2] + (dichlorido(ethylendiamine) aurate(III)-ion) [Au(dach)Cl 2] (dichloride(1,2-diaminocyclohexane) aurate(III)-ion) and [Au(bipy)Cl 2] + (dichlorido(2, 2′-bipyridyl)aurate(III)-ion) with guanosine5′-monophosphate (5′-GMP). It was shown that 5′-GMP have a high affinity for gold(III) complex, which may have important biological implications, since the interactions of Au(III) with DNA are thought to be responsible for the anti-tumor activity. The [Au(bipy)Cl 2] + complex is more reactive than [Au(en)Cl 2] + or [Au(dach)Cl 2] +. The activation parameters for all studied reactions suggest an associative substitution mechanism. The cytotoxicity of gold(III) complexes was tested on A549 human lung carcinoma epithelial cell line and was evaluated by cytotoxic (MTT and LDH test) and apoptotic assays. The results showed that all tested gold(III) complexes displayed cytotoxic effect on A549 cells. Among the tested gold (III) complexes, AuBIPY showed the best cytotoxic effects. © 2012 Bentham Science Publishers.-
dc.relation.ispartofMedicinal Chemistry-
dc.titleCytotoxicity of gold(III) complexes on A549 human lung carcinoma epithelial cell line-
dc.typearticle-
dc.identifier.doi10.2174/157340612799278469-
dc.identifier.scopus84858176756-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)

57

Downloads(s)

1

Files in This Item:
File Description SizeFormat 
PaperMissing.pdf
  Restricted Access
29.86 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.