Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10180
Title: Palladium(II) complexes with R<inf>2</inf>edda derived ligands. Part IV. O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(4-methyl)- pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral activity against chronic lymphocytic leukemia (CLL) cells
Authors: Vujic J.
Cvijović M.
Kaluerovic G.
Milovanovic, Marija
Zmejkovski B.
Volarevic, Vladislav
Arsenijevic, Nebojsa
Sabo, Tibor
Trifunović, Srećko
Journal: European Journal of Medicinal Chemistry
Issue Date: 1-Sep-2010
Abstract: Four novel bidentate N,N′-ligand precursors, including O,O′-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1·2HCl-L4·2HCl, of (S,S)-ethylenediamine-N,N′-di-2-(4- methyl)-pentanoic acid dihydrochloride [(S,S)-H4eddl]Cl2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, 1H NMR and 13C NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr2eddl}], was found to be 13.6 times more active than cisplatin on CLL cells. Compounds R2edda·2HCl-type esters (L1·2HCl-L4·2HCl) and corresponding palladium(II) complexes (1-4) were synthesized, characterized and tested in vitro against chronic lymphocytic leukemia cells. Cytotoxicity depends on ester R substituents in both esters (IC50: nPe < nBu ≈ nPr < Et) and palladium(II) complexes (IC50: nPr < nPe < nBu ≈ Et). The most active compound 2, [PdCl2{(S,S)-nPr2eddl}], was found to be 13.6 times more active than cisplatin on CLL cells. © 2010 Elsevier Masson SAS. All rights reserved.
URI: https://scidar.kg.ac.rs/handle/123456789/10180
Type: article
DOI: 10.1016/j.ejmech.2010.05.005
ISSN: 02235234
SCOPUS: 77955558644
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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