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Title: Glutathione status in the blood of rats after reticulocytosis induced by phenylhydrazine and bleeding
Authors: Marković, Snežana
Obradović, Ana
Žižić, Jovana
Ognjanovic, Branka
Štajn A.
Saicic Z.
Spasić, Mihajlo
Issue Date: 2010
Abstract: In this experiment, we compared the in vivo effects of phenylhydrazine (PHZ) and bleeding treatment on the redox status and glutathione antioxidative mechanism parameters in the plasma and red blood cells (RBC) of rats. Results showed a lower level of reactive oxygen species (ROS), a higher level of lipid peroxidation and the effective antioxidative role of the glutathione system in the blood of bleeding rats. PHZ-treatment induced higher concentrations of ROS and an accumulation of oxidized glutathione in the plasma, while the glutathione system showed a satisfactory antioxidative capacity in the RBC of rats. When comparing the two anemic groups, the PHZ-treated rats showed marked oxidative stress in the plasma.
Type: article
DOI: 10.2298/ABS1003589M
ISSN: 0354-4664
SCOPUS: 2-s2.0-77955151680
Appears in Collections:Faculty of Science, Kragujevac

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