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Title: Elevated Serum Level of IL-23 Correlates with Expression of VEGF in Human Colorectal Carcinoma
Authors: Ljujic, Biljana
Radosavljevic, Gordana
Jovanovic I.
Pavlović N.
Zdravkovic, Nemanja
Milovanovic, Marija
Aćimović L.
Knezevic M.
Banković D.
Savić Zdravković, Dimitrija
Arsenijevic, Nebojsa
Journal: Archives of Medical Research
Issue Date: 1-Apr-2010
Abstract: Background and Aims: Interleukin-23 (IL-23) has a role in inflammatory bowel diseases (IBD) as a condition of higher risk of colorectal carcinogenesis. Vascular endothelial growth factor (VEGF) is overexpressed in IBD and colorectal carcinoma. Therefore, we aimed at uncovering the relationship between serum level of IL-23 and expression of VEGF in colorectal cancer (CRC) patients and to establish the relationship between VEGF and p53 and serum levels of IL-23, as well as its possible role in carcinogenesis of colorectal carcinomas. Methods: Levels of IL-23 from serum samples of patients with colorectal carcinoma (n = 40) and healthy control samples (n = 37) were examined for IL-23-Ab using an ELISA assay. We also determined the expression of VEGF and p53 by immunohistochemistry in 59 cases of CRC. Results: We found significantly higher serum levels of IL-23 in patients with CRC compared to control subjects (IL-23; mean 189.46 pg/mL vs. mean 34.77 pg/mL, p = 0.033). We also detected higher serum levels of IL-23 in patients with overexpressed VEGF (p = 0.028). Our results also showed that concomitant expression of VEGF and increased serum levels of IL-23 are in positive correlation with histological grade 2 (p <0.05). Conclusions: Our data indicate that serum IL-23 levels are significantly elevated in CRC vs. control patients and are strongly associated with overexpression of VEGF, thus they may play an important role in carcinogenesis of CRC. © 2010 IMSS.
Type: Article
DOI: 10.1016/j.arcmed.2010.02.009
ISSN: 01884409
SCOPUS: 77953522676
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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