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Title: Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N′-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl<inf>2</inf>]·4H<inf>2</inf>O and uns-cis-[Pt(S,S-eddp)Br<inf>2</inf>]
Authors: Djinović V.
Glodjović V.
Vasić G.
Trajkovic, Vladimir
Klisuric, Olivera
Stankovic ́ S.
Sabo, Tibor
Trifunović, Srećko
Journal: Polyhedron
Issue Date: 27-May-2010
Abstract: The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)]·nH2O (S,S-eddp = ethylenediamine-N,N′-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N′-di-S,S-2-propanoic acid (H2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl2]·4H2O and uns-cis-[Pt(S,S-eddp)Br2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin. © 2010 Elsevier Ltd. All rights reserved.
Type: Article
DOI: 10.1016/j.poly.2010.03.004
ISSN: 02775387
SCOPUS: 77953231926
Appears in Collections:Faculty of Science, Kragujevac
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