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Title: Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
Authors: Dekić B.
Đekić, Vera
Radulovic, Niko
Vukicevic, Rastko
Palić R.
Issue Date: 2010
Abstract: A series of new coumarin derivatives has been synthesized by condensation of 4-chloro-3-nitrocoumarin and the appropriate arylamine and sulfonamide in ethyl acetate in the presence of triethylamine. The synthesized compounds were screened for their in vitro antimicrobial activity against thirteen strains of bacteria and three fungal/yeast strains using disk diffusion assays. They were shown to possess a wide range of activities from almost completely inactive compounds to medium active ones. (4-[(5-Chloropyridin-2-yl)amino]-3-nitro-2H-chromen-2-one) showed similar activity against Klebsiella pneumoniae as tetracycline. © 2009 Institute of Chemistry, Slovak Academy of Sciences.
Type: article
DOI: 10.2478/s11696-010-0004-z
ISSN: 0366-6352
SCOPUS: 2-s2.0-77951776687
Appears in Collections:Faculty of Science, Kragujevac

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