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Title: Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q<inf>10</inf> and Vitamin E
Authors: Ognjanovic, Branka
Marković, Snežana
Đorđević, Nevena
Trbojević, Ivana
Štajn A.
Saicic Z.
Issue Date: 2010
Abstract: The aim of this study was to investigate the protective role of coenzyme Q10 (CoQ10, 20mg/kg) and Vitamin E (Vit E, 20IU/kg) alone or in combination against cadmium (Cd, 0.4mg/kg) induced lipid peroxidation and changes in antioxidant defense system in the rat testes. The obtained results showed that Cd increased lipid peroxidation in the testes, suggesting that Cd-induced oxidative stress, while CoQ10 and Vit E treatment reversed this change to control values. Acute intoxication with Cd was followed by significantly decreased activity of antioxidant enzymes (SOD, CAT, GSH-Px, GR and GST). Vitamins C and E concentrations also significantly declined in Cd-exposed rat testes. Treatment with CoQ10 and Vit E reversed Cd-induced alterations of antioxidant defense system and significantly prevented Cd-induced testes damage. These results suggest that both CoQ10 and Vit E function as a potent antioxidant in protection of rats testes against the oxidative stress induced by Cd. © 2009 Elsevier Inc.
Type: article
DOI: 10.1016/j.reprotox.2009.11.009
ISSN: 0890-6238
SCOPUS: 2-s2.0-77949570689
Appears in Collections:Faculty of Science, Kragujevac

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