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Title: New simple synthesis of N-substituted 1,3-oxazinan-2-ones
Authors: Trifunović, Srećko
Dimitrijević D.
Vasić G.
Radulovic, Niko
Vukićević, Miomir
Heinemann F.
Vukicevic R.
Journal: Synthesis
Issue Date: 15-Mar-2010
Abstract: An efficient and simple synthesis of N-substituted 1,3-oxazinan-2-ones was developed that involves a three-component, one-pot reaction of readily available tetraethylammonium bicarbonate, 1,3-dibromopropane, and a primary amine in methanol at room temperature. l-Alanine can be used as the amino component to give the chiral product (2S)-2-(2-oxo-1,3-oxazinan-3-yl)propanoic acid. © Georg Thieme Verlag Stuttgart • New York.
Type: Article
DOI: 10.1055/s-0029-1218642
ISSN: 00397881
SCOPUS: 77749293163
Appears in Collections:Faculty of Science, Kragujevac
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