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Title: Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety
Authors: Ratković, Zoran
Juranić Z.
Stanojkovic, Tatjana
Manojlović, Dragan
Vukicevic R.
Radulovic, Niko
Joksović, Milan
Issue Date: 2010
Abstract: A series of new α,β-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MTT method. Derivative 1l containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of K562 cell lines in comparison with cisplatin as a reference compound. © 2009 Elsevier Inc. All rights reserved.
Type: article
DOI: 10.1016/j.bioorg.2009.09.003
ISSN: 0045-2068
SCOPUS: 2-s2.0-73349113168
Appears in Collections:Faculty of Science, Kragujevac

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