Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10333
Title: Dose-dependent immunomodulatory effects of 10-hydroxy-2-decenoic acid on human monocyte-derived dendritic cells
Authors: Mihajlović, Dušan
Rajkovic I.
Chinou I.
Colic, Miodrag
Issue Date: 2013
Abstract: The effect of 10-hydroxy-2-decenoic acid (10-HDA), the unique component of royal jelly, on maturation and functions of human monocyte-derived dendritic cells (MoDCs) in culture was investigated. It has been shown that 10-HDA, at concentrations higher than 500μM, induces apoptosis of MoDCs. A lower dose (50μM) stimulated T helper (Th)1 and down-regulated Th2 immune responses, as judged by the levels of interferon-gamma (IFN-γ) and interleukin (IL)-4, respectively, in supernatants of 10-HDA-treated MoDCs cultivated with allogeneic CD4+T cells. In contrast, a higher dose of 10-HDA (500μM), although non-cytotoxic, inhibited maturation of lipopolysaccharide (LPS)-stimulated MoDCs. Such treated MoDCs produced lower levels of IL-12, IL-18 and tumour necrosis factor-alpha (TNF-α) and down-regulated both Th1 and Th2 immune responses. In conclusion, our results suggest that 10-HDA exerts different activity on human MoDCs, depending on applied concentrations, which is important when considering its therapeutic immunomodulatory property. © 2013 Elsevier Ltd.
URI: https://scidar.kg.ac.rs/handle/123456789/10333
Type: article
DOI: 10.1016/j.jff.2013.01.031
ISSN: 1756-4646
SCOPUS: 2-s2.0-84876741590
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)

438

Downloads(s)

11

Files in This Item:
File Description SizeFormat 
PaperMissing.pdf
  Restricted Access
29.86 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.