Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10548
Title: Ultrasound-assisted synthesis of 3-(arylamino)-1-ferrocenylpropan-1-ones
Authors: Pejović, Anka
Stevanović, Dragana
Damljanović, Ivan
Vukićević, Miomir
Novakovic, Sladjana B.
Bogdanovic, Goran A.
Mihajilov-Krstev T.
Radulovic, Niko
Vukicevic R.
Issue Date: 2012
Abstract: A successful aza-Michael addition of arylamines to a conjugated enone, acryloylferrocene, has been achieved by ultrasonic irradiation of the mixture of these reactants and the catalyst, i.e., montmorillonite K-10. This solvent-free reaction, yielding ferrocene containing Mannich bases, 3-(arylamino)-1- ferrocenylpropan-1-ones, considered as valuable precursors in organic synthesis, has been performed by using a simple ultrasonic cleaner. Among 17 synthesized β-amino ketones, three were new ones, and these were fully characterized by spectroscopic means. X-Ray crystallographic analysis of three of these crystalline products enabled the insight into the conformational details of these compounds. All compounds were evaluated for their antibacterial activities against six Gram-positive and five Gram-negative strains in a microdilution assay. The observed promising antibacterial activity (with a MIC value of 25 μg/ml (ca. 0.07 μmol/ml) as the best result for almost all tested compounds against Micrococcus flavus) seems not only to be compound but also bacterial species-specific. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland.
URI: https://scidar.kg.ac.rs/handle/123456789/10548
Type: article
DOI: 10.1002/hlca.201200009
ISSN: 0018-019X
SCOPUS: 2-s2.0-84865334176
Appears in Collections:Faculty of Science, Kragujevac

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